266 papers
A supervised, tablet-based intervention involving brief, interactive word-image associations significantly improved language comprehension, vocabulary, and grammar in children aged 2 to 5 from low- to middle-socioeconomic backgrounds, demonstrating that structured, socially guided digital media can effectively support early language development.
This study reveals that pathogenic variants in the epilepsy-associated gene KCNT1 cause severe multisystem developmental defects, including respiratory and cardiac issues, by disrupting multiciliated cell formation in Xenopus through an interaction with Piezo signaling pathways.
By integrating single-cell, spatial, and clonal tracing data, this study reveals that cranial placodes arise from a continuous transcriptional landscape through competitive segregation and transient bipotent states, providing new insights into the developmental mechanisms and evolutionary origins of vertebrate sensory organs.
This study reveals that Apelin signaling, regulated by Vegfc-Vegfr3 via ERK activation, is an indispensable and non-redundant mechanism that drives lymphatic endothelial cell migration and sprouting, thereby establishing a critical coordination between growth factor and GPCR pathways in lymphatic development.
This study demonstrates that phenotypic diversity in Lake Malawi cichlid vertebral counts can evolve through changes in the initial size of the pre-somitic mesoderm rather than by altering the underlying somitogenesis process, highlighting initial conditions as a significant, previously overlooked driver of morphological evolution.
This paper proposes a geometric model using Tangential Action Spaces to explain how planarians store hidden regenerative memory as a bioelectric state displacement, offering a quantitative framework that successfully predicts cryptic phenotypes and re-challenge outcomes based on physiological cost metrics.
This study demonstrates that the balance between proliferation and differentiation in mouse small intestinal organoids is regulated by ligand-specific modulation of EGFR endocytosis, where factors like EGF and EREG differentially control receptor trafficking to dictate cell fate outcomes.
This study establishes a dual-species screening platform to identify that CHD7 deficiency disrupts GnRH neuron development via semaphorin signaling and demonstrates that specific epigenetic modulators can rescue these reproductive defects across species, offering potential therapeutic avenues for CHARGE syndrome.
This study employs a multi-omics approach to characterize the distinct metabolic and proteomic profiles of human primordial germ cell-like cells (hPGCLCs), aiming to elucidate the metabolic barriers hindering their maturation and improve in vitro differentiation protocols.
This study identifies LZTS2 as a novel regulator of craniofacial development that functionally interacts with and modulates DYRK1A dosage, as demonstrated by overlapping expression patterns, synergistic phenotypic effects in Xenopus, and correlated human clinical features.
This study establishes an optimized, field-adaptable cryopreservation protocol using 20% DMSO with trehalose or sucrose to successfully preserve peri-gastrulation veiled chameleon embryos, thereby advancing reptile conservation biobanking and enabling mechanistic developmental studies.
Reduced insulin signaling in *C. elegans* disproportionately delays seam cell divisions relative to molting, triggering a compensatory delay in the subsequent molting program to resynchronize these desynchronized developmental events.
This study demonstrates that the heterochromatin protein HP2 is essential for transcribing AAGAG satellite DNA to facilitate chromatin remodeling during spermatogenesis, and that the resulting failure in this process causes preferential death of Y-bearing spermatids, thereby driving a sex-ratio meiotic drive phenotype in *Drosophila*.
This study reveals that the developmental timing of hematopoietic stem and progenitor cell emergence in zebrafish dictates their lifelong lineage bias, with early-arising cells favoring lymphoid production and late-arising cells skewing toward erythroid lineages, a mechanism driven by divergent transcriptional signatures and Runx1 sensitivity that establishes early immune hierarchies persisting into adulthood.
The paper introduces scMLEAge, a Bayesian statistical framework that accurately predicts the age of individual cells from transcriptomic profiles, outperforming standard regression methods and enabling deeper insights into cellular aging heterogeneity.
This study challenges the prevailing view that Notch-mediated lateral inhibition initiates Neuroblast selection in early Drosophila neurogenesis, demonstrating instead that pre-patterned positional cues along the dorsal-ventral axis determine Neuroblast fate while Notch signaling functions only to stabilize these decisions after delamination begins.
This study demonstrates that artificially inducing lumen rounding in human cerebral organoids via Shroom3-mediated apical constriction alters apical progenitor division orientation toward horizontal cleavage planes, thereby accelerating cell delamination and the emergence of basal progenitors, which establishes tissue geometry as an instructive regulator of early brain development.
This study reveals that stony corals evolved their unique ability to secrete calcium carbonate skeletons by co-opting and rewiring ancestral endomesoderm gene regulatory networks, specifically through the novel cis-regulatory control of the *Brachyury* gene, to specify skeleton-secreting cells.
This study reveals that in the *Drosophila* brain, the glioma-associated protein Psi, expressed in cortex glia, inhibits neural stem cell overproliferation by transcriptionally repressing EGFR ligands, thereby highlighting the critical role of niche-mediated communication in regulating stem cell fate and preventing tumorigenesis.
This study demonstrates that the chromodomain helicase DNA-binding protein 4 (CHD4) acts as an essential transcriptional cofactor for NKX2.2 in pancreatic beta cells, where it represses non-beta cell gene programs like GIRK4 to maintain islet integrity, calcium signaling, and proper insulin secretion.